(+)-Tyrphostin B44

• CAT Number: I010243
• CAS Number: 133550-37-5
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.33
• Purity: ≥95%
• Synonyms: (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide
• InChI: InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
• InChIKey: UMGQVUWXNOJOSJ-DGGAMASNSA-N
• SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 µM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 µM against CALO, INBL and HeLa cells, respectively[1].

Reference

[1]. Soto-Cruz I, et al. The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines. Cancer Invest. 2008 Mar;26(2):136-44.
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