U-101958 Maleate

• CAT Number: I037688
• CAS Number: 224170-09-6
• Molecular Formula: C25H33N3O5
• Molecular Weight: 455.56
• Purity: 98%
• Synonyms: U-101958 Maleate, U 101958 Maleate, U101958 Maleate, U101958, U 101958, U-101958
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[1-Benzylpiperidin-4-yl]-N-methyl-3-propan-2-yloxypyridin-2-amine Maleate
• InChI: InChI=1S/C21H29N3O.C4H4O4/c1-17(2)25-20-10-7-13-22-21(20)23(3)19-11-14-24(15-12-19)16-18-8-5-4-6-9-18;5-3(6)1-2-4(7)8/h4-10,13,17,19H,11-12,14-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: KPYPLDPMBWPEBO-BTJKTKAUSA-N
• SMILES: CC(OC1=CC=CN=C1N(C2CCN(CC3=CC=CC=C3)CC2)C)C.O=C(O)/C=CC(O)=O

U-101958 maleate (Cat No.: I037688) is an experimental compound under investigation for its potential therapeutic applications in the treatment of neurological disorders, particularly those involving dopamine dysregulation. It acts as a selective dopamine receptor modulator, potentially offering benefits for conditions such as Parkinson’s disease and schizophrenia. By influencing dopamine pathways, U-101958 maleate aims to improve symptoms related to motor function and cognitive disturbances. Ongoing research and clinical trials are evaluating its safety, efficacy, and overall potential in treating neurodegenerative and psychiatric conditions.

Reference

1: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Langenegger D, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells. Br J Pharmacol. 1999 Oct;128(3):613-20. PubMed PMID: 10516640; PubMed Central PMCID: PMC1571689.
2: Helmeste DM, Shioiri T, Mitsuhashi M, Tang SW. Binding of [3H]U-101958 to sigma1 receptor-like sites in human cerebellum and neuroblastoma cells. Eur J Pharmacol. 1999 Apr 9;370(2):205-9. PubMed PMID: 10323271.
3: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Bruinvels AT, Geisse S, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96. PubMed PMID: 9692773; PubMed Central PMCID: PMC1565470.