For research use only. Not for therapeutic Use.
U-104 (CAT: I002315) is a potent inhibitor of carbonic anhydrase (CA), specifically targeting CA IX and CA XII with high affinity. It exhibits a binding constant (Ki) of 45.1 nM for CA IX and 4.5 nM for CA XII. While it effectively inhibits the activity of CA IX and CA XII, U-104 demonstrates relatively low inhibition towards CA I and CA II. By selectively targeting CA IX and CA XII, U-104 may have potential applications in cancer therapy, as these isoforms of carbonic anhydrase are often overexpressed in various types of tumors and play roles in maintaining the tumor microenvironment.
| Catalog Number | I002315 |
| CAS Number | 178606-66-1 |
| Synonyms | 4-[[[(4-fluorophenyl) |
| Molecular Formula | C₁₃H₁₂FN₃O₃S |
| Purity | ≥95% |
| Target | Carbonic Anhydrase |
| Solubility | DMSO: ≥ 47 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1] |
| InChI | InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18) |
| InChIKey | YJQZNWPYLCNRLP-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F |
| Reference | <p style=/line-height:25px/> |
