(-)-U-50488 hydrochloride

• CAT Number: I010221
• CAS Number: 114528-79-9
• Molecular Formula: C19H26Cl2N2O.HCl
• Molecular Weight: 405.79
• Purity: ≥95%
• Synonyms: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
• Target: Opioid Receptor
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]acetamide;hydrochloride
• InChI: InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m0./s1
• InChIKey: KGMMGVIYOHGOKQ-APTPAJQOSA-N
• SMILES: CN(C(CC1=CC(Cl)=C(Cl)C=C1)=O)[C@]2([H])CCCC[C@@]2([H])N3CCCC3.Cl

(-)-U-50488 Hydrochloride(CAT: I010221) is a selective κ-opioid receptor (KOR) agonist, widely studied for its role in pain modulation and stress-related pathways. By selectively activating KORs without affecting μ- or δ-opioid receptors, it provides a precise tool for exploring the pharmacological and physiological roles of the κ-opioid system. This compound has been utilized in neuroscience and pharmacology research, particularly in studies on analgesia, mood disorders, and addiction. (-)-U-50488 Hydrochloride is instrumental in advancing the understanding of KOR-targeted therapies and their potential applications in managing pain and psychiatric conditions.