U-73122

• CAT Number: I000478
• CAS Number: 112648-68-7
• Molecular Formula: C₂₉H₄₀N₂O₃
• Molecular Weight: 464.64
• Purity: ≥95%
• Synonyms: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
• Target: 5-Lipoxygenase
• Solubility: DMSO: ＜ 4.8 mg/mL
• Storage: Store at -20C
• InChI: InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• InChIKey: LUFAORPFSVMJIW-ZRJUGLEFSA-N
• SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC

U-73122（Cat No.:I000478）is a potent inhibitor of phospholipase C (PLC), an enzyme crucial in intracellular signal transduction involving calcium mobilization. By blocking PLC activity, U-73122 reduces the formation of inositol trisphosphate (IP3) and diacylglycerol (DAG), thereby dampening calcium-dependent signaling pathways. This inhibition is particularly useful in studying cell signaling, as PLC is involved in diverse processes like cell growth, differentiation, and immune responses. U-73122 is widely applied in pharmacology and biochemical research to explore calcium signaling mechanisms and potential therapeutic approaches for conditions influenced by PLC activity.

Reference

1. Smith RJ, et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther. 1990 May;253(2):688-97.
2. Bleasdale JE, et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther. 1990 Nov;255(2):756-68.
3. Thompson AK, et al. The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation. J Biol Chem. 1991 Dec 15;266(35):23856-62.
4. Yule DI, et al. U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem. 1992 Jul 15;267(20):13830-5.