UAMC-1110

• CAT Number: I037748
• CAS Number: 1448440-52-5
• Molecular Formula: C17H14F2N4O2
• Molecular Weight: 344.3218
• Purity: 98%
• Synonyms: UAMC-1110; UAMC 1110; UAMC1110; SP-13786; SP 13786; SP13786
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
• InChI: InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
• InChIKey: PUOOCZVRHBHJRS-NSHDSACASA-N
• SMILES: O=C(C1=CC=NC2=CC=CC=C12)NCC(N3[C@H](C#N)CC(F)(F)C3)=O

UAMC-1110(CAT: I037748) emerges as a significant compound in the field of enzyme inhibition and therapeutic research. Also known as SP-13786, it represents a novel and potent inhibitor of fibroblast activation protein (FAP). With its low nanomolar inhibitory potency, UAMC-1110 offers promise in targeting FAP-mediated processes. Notably, its high selectivity against related dipeptidyl peptidases (DPPs) such as DPP-IV, DPP9, DPP-II, and prolyl oligopeptidase (PREP) highlights its specificity for FAP.

Reference

1: De Decker A, Vliegen G, Van Rompaey D, Peeraer A, Bracke A, Verckist L, Jansen K, Geiss-Friedlander R, Augustyns K, De Winter H, De Meester I, Lambeir AM, Van der Veken P. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). ACS Med Chem Lett. 2019 Jul 9;10(8):1173-1179. doi: 10.1021/acsmedchemlett.9b00191. PMID: 31413802; PMCID: PMC6691567.
2: Moon ES, Elvas F, Vliegen G, De Lombaerde S, Vangestel C, De Bruycker S, Bracke A, Eppard E, Greifenstein L, Klasen B, Kramer V, Staelens S, De Meester I, Van der Veken P, Rösch F. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. doi: 10.1186/s41181-020-00102-z. PMID: 32728930; PMCID: PMC7391456.
3: Gunderson AJ, Yamazaki T, McCarty K, Phillips M, Alice A, Bambina S, Zebertavage L, Friedman D, Cottam B, Newell P, Gough MJ, Crittenden MR, Van der Veken P, Young KH. Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma. PLoS One. 2019 Feb 6;14(2):e0211117. doi: 10.1371/journal.pone.0211117. PMID: 30726287; PMCID: PMC6364920.