UBP-310

• CAT Number: I009923
• CAS Number: 902464-46-4
• Molecular Formula: C14H14N3O6S+
• Molecular Weight: 352.34
• Purity: ≥95%
• Synonyms: UBP310; UBP 310; UBP-310.;(S)-3-((3-(2-amino-2-carboxyethyl)-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)thiophene-2-carboxylic acid
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4 °C
• IC50: 130 nM
• IUPAC Name: 3-[[3-(2-amino-2-carboxyethyl)-5-methylidene-2,6-dioxopyrimidin-3-ium-1-yl]methyl]thiophene-2-carboxylic acid
• InChI: InChI=1S/C14H13N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,1,5-6,15H2,(H-,19,20,21,22)/p+1
• InChIKey: JKFBXNLABOXGTM-UHFFFAOYSA-O
• SMILES: C=C1C=[N+](C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)CC(C(=O)O)N

UBP-310 (Cat No.: I009923) is a selective ubiquitin-specific protease (USP) inhibitor, targeting the USP10 and USP7 enzymes involved in protein deubiquitination. By inhibiting these deubiquitinating enzymes (DUBs), UBP-310 influences cellular protein homeostasis, impacting processes like DNA repair, apoptosis, and oncogenic pathways. It has been studied for its potential in cancer therapy, particularly in enhancing p53 stabilization and promoting tumor suppression. As a small-molecule inhibitor, UBP-310 represents a promising tool for targeting ubiquitin-proteasome system dysfunctions in various diseases, including cancer and neurodegenerative disorders.

Reference

1:Buldyrev I, Puthussery T, Taylor WR. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 2012 Apr;107(7):1795-807. doi: 10.1152/jn.00924.2011. Epub 2011 Dec 28. PubMed PMID: 22205648; PubMed Central PMCID: PMC3331668.2:Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol. 2010 Dec;78(6):1036-45. doi: 10.1124/mol.110.067934. Epub 2010 Sep 13. PubMed PMID: 20837679; PubMed Central PMCID: PMC2993462.