Ubrogepant

For research use only. Not for therapeutic Use.

  • CAT Number: R021588
  • CAS Number: 1374248-77-7
  • Molecular Formula: C29H26F3N5O3
  • Molecular Weight: 549.55
  • Purity: 98%
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Ubrogepant(Cat No.:R021588)is an oral calcitonin gene-related peptide (CGRP) receptor antagonist used for the acute treatment of migraine attacks with or without aura in adults. By blocking CGRP receptors, Ubrogepant interrupts the pathway responsible for migraine pain, vasodilation, and inflammation. Unlike traditional migraine treatments, Ubrogepant is non-vasoconstrictive, making it a safer option for patients with cardiovascular risk factors. Its rapid onset of action provides effective relief from migraine symptoms, offering a well-tolerated alternative for patients seeking non-opioid, non-triptan treatment options for acute migraine management.


Catalog Number R021588
CAS Number 1374248-77-7
Synonyms

MK-1602; Ubrelvy

Molecular Formula C29H26F3N5O3
Purity 98%
Target CGRP antagonist
Target Protein

Q16602

Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IC50 CGRP receptors: Ki = 0.067 nmol/L
IUPAC Name (3S)-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide
InChI InChI=1S/C29H26F3N5O3/c1-16-20(17-6-3-2-4-7-17)11-22(26(39)37(16)15-29(30,31)32)35-25(38)19-10-18-12-28(13-23(18)34-14-19)21-8-5-9-33-24(21)36-27(28)40/h2-10,14,16,20,22H,11-13,15H2,1H3,(H,35,38)(H,33,36,40)/t16-,20-,22+,28+/m1/s1
InChIKey DDOOFTLHJSMHLN-ZQHRPCGSSA-N
SMILES C[C@@H]1[C@@H](C[C@@H](C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(C[C@@]4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=CC=CC=C6

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