UC-112

• CAT Number: I003411
• CAS Number: 383392-66-3
• Molecular Formula: C22H24N2O2
• Molecular Weight: 348.44
• Purity: ≥95%
• Synonyms: 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol
• Target: IAP
• Solubility: 100 mM in DMSO
• Storage: Store at +4C
• IC50: 0.7-3.4 uM (Cell assay) [1]

UC-112 (CAT: I003411) is a novel and potent inhibitor of apoptosis proteins (IAPs). It demonstrates strong inhibitory activity against cell growth in various cancer cell lines, including human melanoma (A375 and M14) and prostate (PC-3 and DU145) cancer cells, with IC50 values ranging from 0.7 to 3.4 μM. UC-112 also exhibits potent activity against P-glycoprotein (P-gp)-overexpressing multidrug-resistant cancer cells. It activates caspase-3/7 and caspase-9 activities, selectively downregulates survivin levels, and shows a mechanism of action consistent with proteasome inhibition. In vivo, studies demonstrate that UC-112 inhibits tumor growth and reduces levels of X chromosome-linked IAP and survivin in a human melanoma xenograft model. UC-112 holds promise as a potential therapeutic agent for cancer treatment.

Reference

[1]. Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29.