For research use only. Not for therapeutic Use.
UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD?=?22 μM)[1][2].
| Catalog Number | I037764 |
| CAS Number | 637324-45-9 |
| Synonyms | [1-[(2,5-dimethylphenyl)methyl]benzimidazol-2-yl]methanol |
| Molecular Formula | C17H18N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18N2O/c1-12-7-8-13(2)14(9-12)10-19-16-6-4-3-5-15(16)18-17(19)11-20/h3-9,20H,10-11H2,1-2H3 |
| InChIKey | RZRPPZWEPMDGEI-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C)CN2C3=CC=CC=C3N=C2CO |
| Reference | [1]. Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90. [2]. O’Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795. |
