UCB-9260

• CAT Number: I016899
• CAS Number: 1515888-53-5
• Molecular Formula: C₂₆H₂₅N₅O
• Molecular Weight: 423.51
• Purity: ≥95%

UCB-9260(CAT: I016899) is an active compound that has been shown to inhibit tumor necrosis factor (TNF) signaling by stabilizing an asymmetric form of the trimer. It exhibits selectivity for TNF over other members of the TNF superfamily and specifically binds to TNF. By inhibiting TNF signaling, UCB-9260 may have potential therapeutic applications in conditions associated with dysregulated TNF signaling, such as inflammatory diseases.

Reference

[1]. O’Connell J, et al.Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.Nat Commun. 2019 Dec 19;10(1):5795.