UCL-1848 trifluoroacetate salt

For research use only. Not for therapeutic Use.

  • CAT Number: I037779
  • CAS Number: 201147-53-7
  • Molecular Formula: C28H34N42+
  • Molecular Weight: 426.61
  • Purity: 98%
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UCL-1848 trifluoroacetate salt is a selective Ca2+-activated, SK potassium channel blocker.


Catalog Number I037779
CAS Number 201147-53-7
Synonyms

UCL1848, UCL-1848, UCL 1848, UCL-1848 trifluoroacetate salt

Molecular Formula C28H34N42+
Purity 98%
Solubility Soluble in DMSO
Appearance White to off-white solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 8,14-Diaza-1,7(1,4)-diquinolinacyclotetradecaphane trifluoroacetate salt
InChI InChI=1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2/b29-25+,30-26+
InChIKey IOXVWOJJNCBJBX-XDHTVYJESA-P
SMILES c1(NCCCCCNc2c(cccc3)c3[n+]4cc2)c5ccccc5[n+](CCCCC4)cc1
Reference

1: Abdullaev IF, Rudkouskaya A, Mongin AA, Kuo YH. Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation. PLoS One. 2010 Aug 20;5(8):e12304. doi: 10.1371/journal.pone.0012304. PubMed PMID: 20808839; PubMed Central PMCID: PMC2924897.
2: Lopez de Armentia M, Sah P. Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. J Neurophysiol. 2004 Sep;92(3):1285-94. Epub 2004 May 5. PubMed PMID: 15128752.
3: Faber ES, Sah P. Physiological role of calcium-activated potassium currents in the rat lateral amygdala. J Neurosci. 2002 Mar 1;22(5):1618-28. PubMed PMID: 11880492.
4: Shah M, Haylett DG. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. PubMed PMID: 10683185; PubMed Central PMCID: PMC1571896.

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