For research use only. Not for therapeutic Use.
UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].
| Catalog Number | I037787 |
| CAS Number | 1621535-90-7 |
| Synonyms | 3-[(3-anilino-3-oxopropyl)-octylamino]-N-phenylpropanamide |
| Molecular Formula | C26H37N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H37N3O2/c1-2-3-4-5-6-13-20-29(21-18-25(30)27-23-14-9-7-10-15-23)22-19-26(31)28-24-16-11-8-12-17-24/h7-12,14-17H,2-6,13,18-22H2,1H3,(H,27,30)(H,28,31) |
| InChIKey | RHEOHKVMYINBGT-UHFFFAOYSA-N |
| SMILES | CCCCCCCCN(CCC(=O)NC1=CC=CC=C1)CCC(=O)NC2=CC=CC=C2 |
| Reference | [1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. |
