For research use only. Not for therapeutic Use.
UCSF686 dihydrochloride is a control probe for the 5-HT5A receptor partial agonist UCSF678 (Axon 3636). UCSF686 is devoid of 5-HT5A receptor activity, but shows affinity at the 5-HT1A, 5-HT2B, and 5-HT7 receptor subtypes. Its inactive control probe UCSF648 is available as Axon 3634.
KEYWORDS: UCSF686 dihydrochloride | Supplier | 5-HT1A/5-HT2B/5-HT7 ligand | 5A6-86 | UCSF 686 | UCSF-686 | CAS [2637090-56-1] | [2637090-55-0] | Serotonin | 5-HT1A | 5-HT2B | 5-HT7 | Ligand | Receptors
| Catalog Number | I047686 |
| CAS Number | 2637090-56-1 |
| Molecular Formula | C15H19ClN2O2S.2HCl |
| Purity | ≥95% |
| IUPAC Name | N-[(5-chloroquinolin-8-yl)methyl]-3-ethylsulfonylpropan-1-amine |
| InChI | InChI=1S/C15H19ClN2O2S/c1-2-21(19,20)10-4-8-17-11-12-6-7-14(16)13-5-3-9-18-15(12)13/h3,5-7,9,17H,2,4,8,10-11H2,1H3 |
| SMILES | CCS(=O)(=O)CCCNCC1=C2C(=C(C=C1)Cl)C=CC=N2 |
| Reference | KA Levit et al. Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor. J Med Chem. 2022 Mar 10;65(5):4201-4217. |
