For research use only. Not for therapeutic Use.
UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].
| Catalog Number | I017402 |
| CAS Number | 1434515-70-4 |
| Synonyms | 6-methyl-2-[(3-phenoxypropylamino)methyl]-1H-quinolin-4-one |
| Molecular Formula | C20H22N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H22N2O2/c1-15-8-9-19-18(12-15)20(23)13-16(22-19)14-21-10-5-11-24-17-6-3-2-4-7-17/h2-4,6-9,12-13,21H,5,10-11,14H2,1H3,(H,22,23) |
| InChIKey | RPHDOVLXDYWDGF-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)NC(=CC2=O)CNCCCOC3=CC=CC=C3 |
| Reference | [1]. Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386. |
