For research use only. Not for therapeutic Use.
UCT943（Cat No.:I019623）is a potent and selective inhibitor of Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K), a critical enzyme involved in the survival and replication of the malaria parasite. By targeting PfPI4K, UCT943 disrupts the parasite’s intracellular development and prevents its proliferation within red blood cells. It has shown efficacy against multiple stages of the Plasmodium life cycle, including liver-stage parasites, making it a promising candidate for malaria treatment. UCT943 is being explored for its potential to overcome drug resistance and improve outcomes in antimalarial therapies.
| Catalog Number | I019623 |
| CAS Number | 1450666-80-4 |
| Molecular Formula | C₂₂H₂₀F₃N₅O |
| Purity | ≥95% |
| IUPAC Name | [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-piperazin-1-ylmethanone |
| InChI | InChI=1S/C22H20F3N5O/c23-22(24,25)17-7-5-15(6-8-17)19-20(26)28-13-18(29-19)14-1-3-16(4-2-14)21(31)30-11-9-27-10-12-30/h1-8,13,27H,9-12H2,(H2,26,28) |
| InChIKey | GGOFGCMPKAWHEZ-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1)C(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C4=CC=C(C=C4)C(F)(F)F)N |
| Reference | [1]. Brunschwig C, et al. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. |
