For research use only. Not for therapeutic Use.
UE2343 (Cat No.: I037799) is a cognitive enhancer and nootropic compound studied for its potential effects on memory, learning, and neuroprotection. It modulates neurotransmitter systems, particularly glutamatergic and cholinergic pathways, which are crucial for synaptic plasticity and cognitive function. UE2343 has been investigated in neurodegenerative disease models, including Alzheimer’s and cognitive decline disorders. Its role in enhancing cognitive performance makes it a valuable tool in neuroscience research, with potential applications in developing therapies for memory impairment and neurodegenerative conditions.
| CAS Number | 1346013-80-6 |
| Synonyms | UE-2343; UE 2343; UE2343; Xanamem; |
| Molecular Formula | C19H19N5O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone |
| InChI | InChI=1S/C19H19N5O2S/c25-17(12-6-16(27-11-12)13-9-22-23-10-13)24-14-2-3-15(24)8-19(26,7-14)18-20-4-1-5-21-18/h1,4-6,9-11,14-15,26H,2-3,7-8H2,(H,22,23)/t14-,15+,19+ |
| InChIKey | MMZFGTAMARVHAF-QWHZDKJVSA-N |
| SMILES | C(C1C=C(C2=CNN=C2)SC=1)(N1[C@@]([H])2CC[C@@]1([H])C[C@](O)(C1=NC=CC=N1)C2)=O |
| Reference | Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. PMID: 28012176; PMCID: PMC5301048. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
