For research use only. Not for therapeutic Use.
UE2343 (Xanamem) is a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor.
| Catalog Number | I037799 |
| CAS Number | 1346013-80-6 |
| Synonyms | UE-2343; UE 2343; UE2343; Xanamem; |
| Molecular Formula | C19H19N5O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone |
| InChI | InChI=1S/C19H19N5O2S/c25-17(12-6-16(27-11-12)13-9-22-23-10-13)24-14-2-3-15(24)8-19(26,7-14)18-20-4-1-5-21-18/h1,4-6,9-11,14-15,26H,2-3,7-8H2,(H,22,23)/t14-,15+,19+ |
| InChIKey | MMZFGTAMARVHAF-QWHZDKJVSA-N |
| SMILES | C(C1C=C(C2=CNN=C2)SC=1)(N1[C@@]([H])2CC[C@@]1([H])C[C@](O)(C1=NC=CC=N1)C2)=O |
| Reference | Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. PMID: 28012176; PMCID: PMC5301048. |
