UF 010

• CAT Number: I003966
• CAS Number: 537672-41-6
• Molecular Formula: C₁₁H₁₅BrN₂O
• Molecular Weight: 271.15
• Purity: ≥95%
• Synonyms: 4-bromo-benzoic acid, 2-butylhydrazide
• Target: HDAC
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)
• InChI: 1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
• InChIKey: BVQCFCYPFJOOAV-UHFFFAOYSA-N
• SMILES: CCCCNNC(=O)C1=CC=C(C=C1)Br

UF010(CAT: I003966) exhibits strong inhibitory activity against HDACs 3, 2, 1, and 8 with IC50 values ranging from 0.06 μM to 1.5 μM. It demonstrates selectivity for these HDAC isoforms over other HDACs. UF010 acts as a competitive inhibitor with a fast-on/slow-off binding mechanism to HDACs. In vitro studies have shown that UF010 promotes the accumulation of acetylated histones, leading to cell cycle arrest at the G1/S transition and inhibiting the proliferation of various cancer cell lines. It also activates tumor suppression mechanisms while inhibiting oncogenic pathways.

Reference

[1]. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015 Feb 19;22(2):273-284.