UK 14,304

• CAT Number: I004242
• CAS Number: 59803-98-4
• Molecular Formula: C11H10BrN5
• Molecular Weight: 292.13
• Purity: ≥95%
• Synonyms: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
• Target: Adenosine Receptor
• Solubility: 100 mM in DMSO
• Storage: Store at -20C

UK 14,304 (Cat.No:I004242) is a synthetic compound that acts as a selective α2-adrenergic receptor agonist. It has been used in pharmacological research to study the role of α2-adrenergic receptors in various physiological processes, including blood pressure regulation, analgesia, and the central nervous system. UK 14,304 may hold potential in the treatment of certain medical conditions.

Reference

[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.

[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.

[3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.