For research use only. Not for therapeutic Use.
UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
IC50 value: 44 nM
Target: procollagen C-proteinase
UK-383367 (UK 383367) is useful for anti-scarring agent
| Catalog Number | I003277 |
| CAS Number | 348622-88-8 |
| Synonyms | 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide |
| Molecular Formula | C15H24N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1 |
| InChIKey | ARJCBSRIPGJMAD-LLVKDONJSA-N |
| SMILES | C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N |
| Reference | [1]. Allan GA, et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006 May;36(5):399-418. |
