UK-5099

• CAT Number: I004108
• CAS Number: 56396-35-1
• Molecular Formula: C₁₈H₁₂N₂O₂
• Molecular Weight: 288.31
• Purity: ≥95%
• Synonyms: (E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid
• Target: Mitochondrial Metabolism
• Solubility: DMSO >20 mg/mL
• Storage: Store at -20°C
• IC50: 50 nM
• InChI: InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
• InChIKey: BIZNHCWFGNKBBZ-JLHYYAGUSA-N
• SMILES: C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O

UK-5099 (CAT: I004108)) is a potent and selective inhibitor of monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC). By targeting these critical transporters, UK-5099 disrupts pyruvate metabolism and lactate transport, making it a valuable tool for studying cellular energy metabolism and metabolic reprogramming. It is widely used in research focused on cancer metabolism, diabetes, and other metabolic disorders, as these conditions often involve altered pyruvate and lactate dynamics. With its high specificity and efficacy, UK-5099 supports investigations into mitochondrial function, metabolic pathway regulation, and the development of novel therapeutic strategies targeting metabolic pathways.