UKI-1

• CAT Number: I002686
• CAS Number: 220355-63-5
• Molecular Formula: C32H47N5O5S
• Molecular Weight: 613.81
• Purity: ≥95%
• Target: PAI-1
• Solubility: DMSO ≥ 28 mg/mL
• Storage: Store at -20°C

UKI-1 (Cat.No:I002686) is a novel synthetic inhibitor of the urokinase-type plasminogen activator system. It can also inhibits the invasive capacity of carcinoma cells. (Ki=0.41 μM)In vitro : A decrease of tumor cell invasion by up to 50% was achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa after treatment with UK1.

Reference

[1]. Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24.

[2]. Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.