ULK-101

• CAT Number: I019446
• CAS Number: 2443816-45-1
• Molecular Formula: C₂₂H₁₆F₄N₄OS
• Molecular Weight: 460.45
• Purity: ≥95%
• Target: ULK

ULK-101 (Cat.No:I019446) is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress. ULK-101 (0-5 μM) reduces BafA1-induced LC3B-II accumulation in U2OS cells in a concentration-dependent manner.

Reference

[1]. Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.