UMI-77-d4

• CAT Number: R026012
• CAS Number: NA
• Molecular Formula: C₁₈H₁₀D₄BrNO₅S₂
• Molecular Weight: 472.37
• Purity: ≥95%
• Synonyms: [[4-[[(4-Bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]scetic Acid-d4;?2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic Acid-d4
• Storage: Store at -20C
• IUPAC Name: 2-[4-[(4-bromo-2,3,5,6-tetradeuteriophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic aci
• InChI: InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)/i5D,6D,7D,8D
• InChIKey: WUGANDSUVKXMEC-KDWZCNHSSA-N

UMI-77-d4 is a deuterated derivative of UMI-77, a small-molecule inhibitor that specifically targets the anti-apoptotic protein Mcl-1, a member of the Bcl-2 family. By inhibiting Mcl-1, UMI-77-d4 promotes apoptosis in cancer cells, making it valuable in cancer research. The deuterium labeling in UMI-77-d4 is used to study the compound’s pharmacokinetics, improving the accuracy of metabolic and bio-distribution analyses. This compound is particularly useful in pharmaceutical research for the development of targeted cancer therapies, as well as in studies involving organic and medicinal chemistry.