Umirolimus

• CAT Number: R002451
• CAS Number: 851536-75-9
• Molecular Formula: C55H87NO14
• Molecular Weight: 986.30
• Purity: ≥95%
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-12-[(2R)-1-[(1S,3R,4R)-4-(2-ethoxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• InChI: InChI=1S/C55H87NO14/c1-12-67-26-27-68-45-24-22-41(31-48(45)65-10)30-37(5)47-33-44(57)36(4)29-39(7)50(59)51(66-11)49(58)38(6)28-34(2)18-14-13-15-19-35(3)46(64-9)32-42-23-21-40(8)55(63,70-42)52(60)53(61)56-25-17-16-20-43(56)54(62)69-47/h13-15,18-19,29,34,36-38,40-43,45-48,50-51,59,63H,12,16-17,20-28,30-33H2,1-11H3/b15-13+,18-14+,35-19+,39-29+/t34-,36-,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,55-/m1/s1
• InChIKey: YYSFXUWWPNHNAZ-PKJQJFMNSA-N
• SMILES: CCOCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]2CC(=O)[C@@H](/C=C(/[C@H]([C@H](C(=O)[C@@H](C[C@@H](/C=C/C=C/C=C(/[C@H](C[C@@H]3CC[C@H]([C@@](O3)(C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)O)C)OC)\C)C)C)OC)O)\C)C

Umirolimus（Cat No.:R002451）is an immunosuppressive drug and mTOR inhibitor derived from sirolimus, primarily used in drug-eluting stents to prevent restenosis in coronary artery disease. By inhibiting the mammalian target of rapamycin (mTOR), umirolimus reduces smooth muscle cell proliferation and migration, which helps prevent the narrowing of blood vessels post-stent implantation. Its targeted action minimizes scarring in the arterial walls, enhancing stent efficacy and improving long-term patient outcomes. Known for its potent effects with lower dosing requirements, umirolimus is valuable in cardiovascular treatments and biomedical device applications.

Reference

A process of the preparation of O-alkylated rapamycin derivative. Isozaki M. & Kawanishi T. US Patent 7,193,078, 2007. To Market, To Market – 2008. Hegde S. & Schmidt M. Annual Reports in Medicinal Chemistry Chapter 28 (Ed. John E. Macor) 2009, 44, 577.