For research use only. Not for therapeutic Use.
UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].
| Catalog Number | I037831 |
| CAS Number | 342595-74-8 |
| Synonyms | 5-(4-methylphenyl)-4-pyrrolidin-1-ylthieno[2,3-d]pyrimidine |
| Molecular Formula | C17H17N3S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H17N3S/c1-12-4-6-13(7-5-12)14-10-21-17-15(14)16(18-11-19-17)20-8-2-3-9-20/h4-7,10-11H,2-3,8-9H2,1H3 |
| InChIKey | VOAWQTDHSSKEKA-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=CSC3=NC=NC(=C23)N4CCCC4 |
| Reference | [1]. Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763. |
