For research use only. Not for therapeutic Use.
Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC<sub>50</sub> values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC<sub>50</sub> = 70 nM). Cell permeable.
| Catalog Number | I010939 |
| CAS Number | 1255517-77-1 |
| Synonyms | 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
| Molecular Formula | C30H47N5O2 |
| Purity | ≥95% |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in 1eq. HCl |
| Storage | Store at +4C |
| IUPAC Name | 2-cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine |
| InChI | InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33) |
| InChIKey | QOECJCJVIMVJGX-UHFFFAOYSA-N |
| SMILES | CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5 |
