UNC 0638

• CAT Number: I010939
• CAS Number: 1255517-77-1
• Molecular Formula: C30H47N5O2
• Molecular Weight: 509.74
• Purity: ≥95%
• Synonyms: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in 1eq. HCl
• Storage: Store at +4C
• IUPAC Name: 2-cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
• InChI: InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
• InChIKey: QOECJCJVIMVJGX-UHFFFAOYSA-N
• SMILES: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5

UNC 0638（Cat No.:I010939）is a potent and selective inhibitor of the protein lysine-specific demethylase 1 (LSD1), an enzyme involved in the regulation of gene expression through the demethylation of histones. LSD1 plays a key role in various biological processes, including cell differentiation, proliferation, and cancer progression. By inhibiting LSD1, UNC 0638 aims to modulate gene expression patterns and has shown potential in preclinical studies for cancer therapy, particularly in hematological malignancies and solid tumors. It is also being explored for its possible therapeutic applications in neurodegenerative diseases and other disorders involving epigenetic dysregulation.