For research use only. Not for therapeutic Use.
UNC0379 (CAT: I002080) is a selective inhibitor of the lysine methyltransferase SETD8. It acts as a substrate-competitive inhibitor, specifically targeting the catalytic activity of SETD8. By inhibiting SETD8, UNC0379 can modulate the methylation of histone H4 at lysine 20 (H4K20), which is a critical epigenetic modification involved in gene expression regulation. The selective inhibition of SETD8 by UNC0379 offers potential for studying the role of SETD8-mediated methylation in cellular processes and for developing therapeutic strategies targeting SETD8 in diseases where dysregulation of H4K20 methylation is implicated.
| Catalog Number | I002080 |
| CAS Number | 1620401-82-2 |
| Synonyms | 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine |
| Molecular Formula | C₂₃H₃₅N₅O₂ |
| Purity | ≥95% |
| Target | Histone Methyltransferase |
| Solubility | 10 mM in DMSO |
| Storage | Desiccate at -20C |
| IC50 | 7.3±1.0 uM |
| InChI | InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26) |
| InChIKey | WEXCGGWTIDNVNT-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC |
| Reference | <p style=/line-height:25px/> |
