For research use only. Not for therapeutic Use.
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].
UNC10201652 exhibits potently inhibitory activity against wild type E. coli with an EC50 of 74±7 nM[2].
| Catalog Number | I042911 |
| CAS Number | 372495-52-8 |
| Synonyms | 4-(13-piperazin-1-yl-11-thia-9,14,15,16-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(10),2(7),8,12(17),13,15-hexaen-8-yl)morpholine |
| Molecular Formula | C20H25N7OS |
| Purity | ≥95% |
| InChI | InChI=1S/C20H25N7OS/c1-2-4-14-13(3-1)15-16-17(19(24-25-23-16)26-7-5-21-6-8-26)29-20(15)22-18(14)27-9-11-28-12-10-27/h21H,1-12H2 |
| InChIKey | ZPVQONCMKZBGTB-UHFFFAOYSA-N |
| SMILES | C1CCC2=C(C1)C3=C(N=C2N4CCOCC4)SC5=C3N=NN=C5N6CCNCC6 |
| Reference | [1]. Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15(1):217-225. [2]. Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4(7):868-879. |
