UNC2399

• CAT Number: I044502
• CAS Number: 2412791-72-9
• Molecular Formula: C67H104N10O17S
• Molecular Weight: 1353.66
• Purity: ≥95%

UNC2399, a biotinylated UNC1999, is a selective EZH2 inhibitor, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].
UNC2399 (1-1000 nM) displays high in vitro potency (IC50=17±2 nM) in the EZH2 radioactive biochemical assay[1].
UNC2399 (100 μM) enriches EZH2 from HEK293T cell lysates[1].

Reference

[1]. Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6): 1324-34.
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[2]. Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.
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