UNC3866

• CAT Number: I002422
• CAS Number: 1872382-47-2
• Molecular Formula: C43H66N6O8
• Molecular Weight: 795
• Purity: ≥95%
• Synonyms: N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine, methyl ester
• Target: Histone Methyltransferase
• Solubility: DMSO: ≥ 27 mg/mL
• Storage: -20°C
• InChIKey: UMRRDXVUROEIKJ-JCXBGQGISA-N

UNC3866 (CAT: I002422) is a potent antagonist that targets the CBX7-H3 interaction. It has been determined through AlphaScreen analysis to have an IC50 value of 66±1.2 nM. UNC3866 demonstrates high selectivity for CBX7 over other members of the methyl-lysine (Kme) reader panel, with more than 100-fold selectivity observed. CBX7 is a protein involved in recognizing and binding to specific methylated lysine residues, playing a role in chromatin regulation and gene expression. UNC3866’s ability to selectively disrupt the CBX7-H3 interaction offers potential applications in epigenetic research and the development of therapies targeting CBX7-related processes.

Reference

[1]. Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7.