For research use only. Not for therapeutic Use.
UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC50s of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively[1].
Mice are treated with UNC4203 (compound 24) at a dose of 10 mg/kg administered via oral (po) or iv routes. Under the condition, UNC4203 (compound 24) has 58% oral bioavailability with a 7.8 h half-life, 1.7 L/kg volume of distribution, and 36 mL/min/kg clearance[1].
| Catalog Number | I037836 |
| CAS Number | 1818234-19-3 |
| Synonyms | 4-[5-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol |
| Molecular Formula | C30H44N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C30H44N6O/c1-4-6-22(2)32-30-31-19-27-28(21-36(29(27)33-30)25-11-13-26(37)14-12-25)24-9-7-23(8-10-24)20-35-16-5-15-34(3)17-18-35/h7-10,19,21-22,25-26,37H,4-6,11-18,20H2,1-3H3,(H,31,32,33)/t22-,25?,26?/m0/s1 |
| InChIKey | HYUGTGGDEAGXJP-OIEGUCRUSA-N |
| SMILES | CCCC(C)NC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCCN(CC5)C |
| Reference | [1]. Hongchao Zheng, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 Aug 5;220:113534. |
