UNC6934

• CAT Number: I045182
• CAS Number: 2561494-77-5
• Molecular Formula: C24H21N5O4
• Molecular Weight: 443.45
• Purity: ≥95%
• Synonyms: N-cyclopropyl-3-oxo-N-[[4-(pyrimidin-4-ylcarbamoyl)phenyl]methyl]-4H-1,4-benzoxazine-7-carboxamide
• InChI: InChI=1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31)
• InChIKey: KOZGEDUWAQFVAV-UHFFFAOYSA-N
• SMILES: C1CC1N(CC2=CC=C(C=C2)C(=O)NC3=NC=NC=C3)C(=O)C4=CC5=C(C=C4)NC(=O)CO5

UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.

Reference

[1]. Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.
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