UNC7145

• CAT Number: I047679
• CAS Number: 2561494-78-6
• Molecular Formula: C24H23N5O4
• Molecular Weight: 445.47
• Purity: ≥95%
• IUPAC Name: 3-oxo-N-propan-2-yl-N-[[4-(pyrimidin-4-ylcarbamoyl)phenyl]methyl]-4H-1,4-benzoxazine-7-carboxamide
• InChI: InChI=1S/C24H23N5O4/c1-15(2)29(24(32)18-7-8-19-20(11-18)33-13-22(30)27-19)12-16-3-5-17(6-4-16)23(31)28-21-9-10-25-14-26-21/h3-11,14-15H,12-13H2,1-2H3,(H,27,30)(H,25,26,28,31)
• SMILES: CC(C)N(CC1=CC=C(C=C1)C(=O)NC2=NC=NC=C2)C(=O)C3=CC4=C(C=C3)NC(=O)CO4

A chemically related negative control compound for UNC6934 (Axon 3591), a potent and selective chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
KEYWORDS: UNC7145 | Supplier | NSD2-PWWP1 negative control | UNC 7145 | UNC-7145 | CAS [2561494-78-6] | Histone | HMTase | Inhibitor | Enzymes | Multiple myeloma | WHSC1 | MMSET | PHD

Reference

D Dilworth et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.