UNC7467

• CAT Number: I047689
• CAS Number: 2922283-43-8
• Molecular Formula: C20H13NO3
• Molecular Weight: 315.32
• Purity: ≥95%
• IUPAC Name: 3-(4-phenylphenyl)-2,1-benzoxazole-5-carboxylic acid
• InChI: InChI=1S/C20H13NO3/c22-20(23)16-10-11-18-17(12-16)19(24-21-18)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12H,(H,22,23)
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C=C(C=CC4=NO3)C(=O)O

UNC7467 is a potent IP6K inhibitor with IC50 values of 8.9 nM, 4.9 nM and 1320 nM for IP6K1, IP6K2 and IP6K3, respectively. In vivo, UNC7467 reduced body weight gain in the context of a high-fat diet, decreased fat, ameliorated hepatic steatosis, and improved glycemic profiles in diet-induced obese mice.
Keywords: UNC7467 | Supplier | IP6K inhibitor | UNC 7467 | UNC-7467 | CAS [2922283-43-8] | Inositol hexakisphosphate (InsP6) | ITPK | Inhibitor | Enzymes | Obesity | Obesity-induced metabolic dysfunction

Reference

Y Zhou et al. Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. J Med Chem. 2022 May 12;65(9):6869-6887.