UNC8153

• CAT Number: I047508
• CAS Number: 2929304-60-7
• Molecular Formula: C33H37N5O5
• Molecular Weight: 583.68
• Purity: ≥95%

UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism.

Reference

[1] Hanley RP, et al. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188.