UNC8732

• CAT Number: I047740
• CAS Number: 2929304-05-0
• Molecular Formula: C35H39N5O5
• Molecular Weight: 609.72
• Purity: ≥95%
• IUPAC Name: molecular hydrogen
• InChI: InChI=1S/6H2/h6*1H
• SMILES: [HH].[HH].[HH].[HH].[HH].[HH]

UNC8732 is a second-generation NSD2 degrader (DC50 value of 60 nM; Dmax of 97%) that demonstrates improved NSD2 degradation and H3K36me2 reduction in cells. UNC8732 contains a primary alkyl amine, which is metabolized in cells to an active aldehyde species that promotes NSD2 degradation through the recruitment of FBXO22, a substrate recognition subunit of a Cullin 1 E3 ligase complex. KEYWORDS: UNC8732 | Supplier | NSD2 degrader | UNC 8732 | UNC-8732 | CAS [2929304-05-0] | [2929304-06-1] | Histone | HMTase | Inhibitor | Enzymes | FBXO22 | Cullin 1 E3 ligase complex | Targeted protein degradation | TPD | Histone methyltransferase

Reference

DY Nie et al. Recruitment of FBXO22 for targeted degradation of NSD2. Nat Chem Biol. 2024 Jul 4;0(0):10.