Unesbulin HCl

• CAT Number: I037853
• Molecular Formula: C19H14ClF5N6
• Molecular Weight: 456.81
• Purity: 98%
• Synonyms: PTC596; PTC-596; PTC 596; Unesbulin HCl; Unesbulin hydrochloride
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-Fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine hydrochloride
• InChI: InChI=1S/C19H13F5N6.ClH/c1-9-26-13-7-4-11(20)8-14(13)30(9)18-28-16(25)15(21)17(29-18)27-12-5-2-10(3-6-12)19(22,23)24;/h2-8H,1H3,(H3,25,27,28,29);1H
• InChIKey: HMSRJQMYSGRRPF-UHFFFAOYSA-N
• SMILES: NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C(C)=NC4=CC=C(F)C=C34)=N1.[H]Cl

Unesbulin HCl(CAT: I037853) is a novel microtubule destabilizer with potent anticancer properties, extensively studied for its role in disrupting microtubule dynamics and inhibiting tumor cell proliferation. By targeting microtubules, it induces cell cycle arrest and apoptosis, making it valuable in oncology research. The hydrochloride form enhances its solubility and bioavailability, ensuring effective experimental application. Unesbulin HCl is particularly relevant in investigating solid tumors and hematologic malignancies, offering insights into its therapeutic potential as a standalone agent or in combination therapies. Its specificity and efficacy provide researchers with a critical tool for advancing cancer treatment strategies.