For research use only. Not for therapeutic Use.
Unesbulin (Cat No.: I018285), also known as PTC596, is a second-generation BMI-1 inhibitor that can accelerate the degradation of BMI-1. PTC596 downregulates MCL-1 and induces p53-dependent mitochondrial apoptosis. Mantle cell lymphoma cells were treated for 72 hours with IC50 of 68-340nM.
| Catalog Number | I018285 |
| CAS Number | 1610964-64-1 |
| Molecular Formula | C₁₉H₁₃F₅N₆ |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | Store at -20°C |
| IUPAC Name | 5-fluoro-2-(6-fluoro-2-methylbenzimidazol-1-yl)-4-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine |
| InChI | InChI=1S/C19H13F5N6/c1-9-26-13-7-4-11(20)8-14(13)30(9)18-28-16(25)15(21)17(29-18)27-12-5-2-10(3-6-12)19(22,23)24/h2-8H,1H3,(H3,25,27,28,29) |
| InChIKey | TWLWOOPCEXYVBE-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(N1C3=NC(=C(C(=N3)NC4=CC=C(C=C4)C(F)(F)F)F)N)C=C(C=C2)F |
| Reference | [1]. Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7(2):e527.<br>[2]. BMI1 inhibitor PTC596 |
