Unifiram

• CAT Number: I037854
• CAS Number: 272786-64-8
• Molecular Formula: C13H15FN2O3S
• Molecular Weight: 298.33
• Purity: 98%
• Synonyms: Unifiram; DM232; DM 232; DM-232
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo(1,2-a)pyrazin-6(2H)-one
• InChI: InChI=1S/C13H15FN2O3S/c14-10-1-4-12(5-2-10)20(18,19)15-7-8-16-11(9-15)3-6-13(16)17/h1-2,4-5,11H,3,6-9H2
• InChIKey: SNRTZFZAFBIBJP-UHFFFAOYSA-N
• SMILES: O=C1CCC2CN(S(=O)(C3=CC=C(F)C=C3)=O)CCN21

Unifiram(CAT: I037854) emerges as a nootropic agent recognized for its cognitive-enhancing properties. Operating through intricate mechanisms, it promotes the release of acetylcholine (ACh) within the rat cerebral cortex, resulting in heightened field excitatory postsynaptic potentials (fEPSPs) in the hippocampal CA1 region, with an effective concentration (EC50) of 27 nM. Distinguishing itself from binding to numerous receptors at 1 µM, including serotonin, dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, and GABA receptors, Unifiram exhibits selectivity. Demonstrating its cognitive impact, Unifiram enhances memory in rats through social learning tests and safeguards against memory deficits induced by various agents in mice’s passive avoidance tests.