For research use only. Not for therapeutic Use.
UoS 12258 is a positive allosteric modulator of AMPA receptors.
| Catalog Number | I037860 |
| CAS Number | 875927-64-3 |
| Synonyms | UoS 12258; UoS12258; UoS-12258 |
| Molecular Formula | C17H19FN2O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide |
| InChI | InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1 |
| InChIKey | QXQSUBKWSHMXDP-INIZCTEOSA-N |
| SMILES | CC(S(=O)(N[C@H]1CC2=C(C=C(C3=CC=C(F)N=C3)C=C2)C1)=O)C |
| Reference | Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID: 20614889 |
