For research use only. Not for therapeutic Use.
UoS 12258（Cat No.:I037860）is a selective inhibitor of the protein kinase CK2 (casein kinase 2), an enzyme that regulates various cellular processes, including cell proliferation, survival, and apoptosis. CK2 is often overexpressed in cancer cells and is implicated in tumor growth and resistance to therapy. By inhibiting CK2, UoS 12258 aims to disrupt these oncogenic processes, making it a potential candidate for cancer treatment. Preclinical studies suggest that UoS 12258 may enhance the effectiveness of chemotherapy and targeted therapies, but further research and clinical trials are necessary to fully evaluate its therapeutic potential and safety profile.
| Catalog Number | I037860 |
| CAS Number | 875927-64-3 |
| Synonyms | UoS 12258; UoS12258; UoS-12258 |
| Molecular Formula | C17H19FN2O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-[(2S)-5-(6-fluoropyridin-3-yl)-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide |
| InChI | InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1 |
| InChIKey | QXQSUBKWSHMXDP-INIZCTEOSA-N |
| SMILES | CC(C)S(=O)(=O)N[C@H]1CC2=C(C1)C=C(C=C2)C3=CN=C(C=C3)F |
| Reference | Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID: 20614889 |
