UPF-648

• CAT Number: I002642
• CAS Number: 213400-34-1
• Molecular Formula: C11H8Cl2O3
• Molecular Weight: 259.09
• Purity: ≥95%
• Target: KMO inhibitor
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 1 uM(81 ± 10 % inhibition) [1]

UPF-648 (Cat.No:I002642) is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

Reference

[1]. Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109(2):316-25.
[2]. Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85(4):845-54.
[3]. Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5.