Uracil-d2

• CAT Number: I041647
• CAS Number: 24897-52-7
• Molecular Formula: C4H2D2N2O2
• Molecular Weight: 114.10
• Purity: ≥95%
• Synonyms: 5,6-dideuterio-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)/i1D,2D
• InChIKey: ISAKRJDGNUQOIC-QDNHWIQGSA-N
• SMILES: C1=CNC(=O)NC1=O

Uracil-d2 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.
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