For research use only. Not for therapeutic Use.
URAT1 inhibitor 6 (CAT: I040906) is a highly potent inhibitor of the urate transporter 1 (hURAT1), with an IC50 value of 35 nM. It is significantly more potent than the parent compounds Lesinurad (200-fold) and Benzbromarone (8-fold). By inhibiting URAT1, Compound 1h reduces uric acid reabsorption in the kidneys, which can help in managing hyperuricemia and related inflammatory conditions. The compound’s enhanced potency makes it a valuable tool for research into inflammation, particularly in conditions like gout, where elevated uric acid levels lead to inflammatory responses. It holds promise for developing new treatments for gout and other inflammatory disorders.
| CAS Number | 2244807-49-4 |
| Synonyms | sodium;2-[[5-bromo-4-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate |
| Molecular Formula | C9H7BrN3NaO2S2 |
| Purity | ≥95% |
| IUPAC Name | sodium;2-[[5-bromo-4-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate |
| InChI | InChI=1S/C9H8BrN3O2S2.Na/c10-8-11-12-9(17-5-7(14)15)13(8)4-6-2-1-3-16-6;/h1-3H,4-5H2,(H,14,15);/q;+1/p-1 |
| InChIKey | YOLZEFFEYBRHAT-UHFFFAOYSA-M |
| SMILES | C1=CSC(=C1)CN2C(=NN=C2Br)SCC(=O)[O-].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
