For research use only. Not for therapeutic Use.
URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation[1].
| Catalog Number | I040906 |
| CAS Number | 2244807-49-4 |
| Synonyms | sodium;2-[[5-bromo-4-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate |
| Molecular Formula | C9H7BrN3NaO2S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H8BrN3O2S2.Na/c10-8-11-12-9(17-5-7(14)15)13(8)4-6-2-1-3-16-6;/h1-3H,4-5H2,(H,14,15);/q;+1/p-1 |
| InChIKey | YOLZEFFEYBRHAT-UHFFFAOYSA-M |
| SMILES | C1=CSC(=C1)CN2C(=NN=C2Br)SCC(=O)[O-].[Na+] |
| Reference | [1]. Cai W, et al. Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor. Molecules. 2018 Jan 27;23(2):252. |
