For research use only. Not for therapeutic Use.
URAT1&XO inhibitor 2 (CAT: I040905) is a dual inhibitor targeting both xanthine oxidase (XO) and urate transporter 1 (URAT1), with an IC50 of 3.3 μM for XO. By inhibiting XO, it reduces the production of uric acid, while its action on URAT1 blocks the reuptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. This dual mechanism leads to a decrease in serum urate levels and reduced uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 is highly relevant for research on hyperuricemia and gout, offering potential for the development of targeted treatments to manage elevated uric acid levels.
| CAS Number | 1239488-96-0 |
| Synonyms | 4-[(E)-C-[(4-bromophenyl)methyl]-N-hydroxycarbonimidoyl]benzene-1,3-diol |
| Molecular Formula | C14H12BrNO3 |
| Purity | ≥95% |
| IUPAC Name | 4-[(E)-C-[(4-bromophenyl)methyl]-N-hydroxycarbonimidoyl]benzene-1,3-diol |
| InChI | InChI=1S/C14H12BrNO3/c15-10-3-1-9(2-4-10)7-13(16-19)12-6-5-11(17)8-14(12)18/h1-6,8,17-19H,7H2/b16-13+ |
| InChIKey | FWPXBKAQCQNVFM-DTQAZKPQSA-N |
| SMILES | C1=CC(=CC=C1CC(=NO)C2=C(C=C(C=C2)O)O)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
