Urease-IN-6

• CAT Number: I040359
• CAS Number: 362502-79-2
• Molecular Formula: C18H19N3OS
• Molecular Weight: 325.43
• Purity: ≥95%
• Synonyms: 1-[2-(1H-indol-3-yl)ethyl]-3-(4-methoxyphenyl)thiourea
• InChI: InChI=1S/C18H19N3OS/c1-22-15-8-6-14(7-9-15)21-18(23)19-11-10-13-12-20-17-5-3-2-4-16(13)17/h2-9,12,20H,10-11H2,1H3,(H2,19,21,23)
• InChIKey: USHGHTOQCIQMRQ-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)NC(=S)NCCC2=CNC3=CC=CC=C32

Urease-IN-6 is a potent inhibitor of Urease with an IC50 of 14.2 μM. Urease-IN-6 can be used in study peptic and gastric ulcers [1].

Reference

[1]. Kanwal, et al. Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies. Bioorg Chem. 2019 Mar;83:595-610.
 [Content Brief]