Ursodeoxycholic acid

• CAT Number: A000588
• CAS Number: 128-13-2
• Molecular Formula: C24H40O4
• Molecular Weight: 392.57
• Purity: ≥95%
• Synonyms: URSODEOXYCHOLIC ACID; Ursodiol; 128-13-2; Actigall; Ursofalk; Ursolvan
• Storage: -20°C
• IUPAC Name: (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• InChI: 1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1
• InChIKey: RUDATBOHQWOJDD-UZVSRGJWSA-N
• SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Ursodeoxycholic acid(CAT: A000588) is one of the components of human bile. It is used in medicine to increase the secretion of bile acid, and reduce cholesterol and cholesterol lipids in bile, which is conducive to the gradual dissolution of cholesterol in gallstones. Recent research has found that it may be used to prevent COVID-19. This product is used for medical research and development and other scientific research purposes.

Overview of Clinical Research

Ursodeoxycholic acid is an apoptosis inhibitor as well as a cholesterol inhibitor. The pilot study on fecal bile acids composition of IBD patients was completed in Aug, 2020.

Reference

1: Einarsson K. Effect of ursodeoxycholic acid on hepatic cholesterol metabolism. Scand J Gastroenterol Suppl. 1994;204:19-23. Review. PubMed PMID: 7824873.
2: van Erpecum KJ, van de Meeberg PC, van Berge Henegouwen GP. Rationale for therapy with ursodeoxycholic acid in patients with cholestatic liver disease. Neth J Med. 1993 Dec;43(5-6):233-8. Review. PubMed PMID: 8107930.
3: Calmus Y, Poupon R. Ursodeoxycholic acid (UDCA) in the treatment of chronic cholestatic diseases. Biochimie. 1991 Oct;73(10):1335-8. Review. PubMed PMID: 1782227.
4: James OF. Ursodeoxycholic acid treatment for chronic cholestatic liver disease. J Hepatol. 1990 Jul;11(1):5-8. Review. PubMed PMID: 2204659.
5: Scharschmidt BF, Lake JR. Hepatocellular bile acid transport and ursodeoxycholic acid hypercholeresis. Dig Dis Sci. 1989 Dec;34(12 Suppl):5S-15S. Review. PubMed PMID: 2689116.