For research use only. Not for therapeutic Use.
Ursolic acid (CAT: I004851) is a naturally occurring pentacyclic triterpenoid found in a variety of plants, including apple peels, rosemary, and holy basil. It possesses multiple pharmacological activities and has been studied for its potential health benefits. Ursolic acid exhibits antioxidant, anti-inflammatory, and anticancer properties. It has also been investigated for its effects on metabolism, muscle growth, and bone health. Ursolic acid has shown potential in protecting against oxidative stress, reducing inflammation, inhibiting tumor growth, and promoting apoptosis in cancer cells. Additionally, it may have beneficial effects on glucose metabolism, lipid profile, and muscle hypertrophy. Ursolic acid represents a promising natural compound with diverse potential applications in health and medicine.
| Catalog Number | I004851 |
| CAS Number | 77-52-1 |
| Synonyms | Bungeolic Acid;Maerotaine;Malol;NSC 4060;NSC 167406;Prunol |
| Molecular Formula | C30H48O3 |
| Purity | ≥95% |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | WCGUUGGRBIKTOS-SVVSFECHSA-N |
| Reference | </br>1:Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: Development, characterization, in vitro and in vivo assessment for the therapy of leishmaniasis. Das S, Ghosh S, De AK, Bera T.Int J Biol Macromol. 2017 Apr 29;102:996-1008. doi: 10.1016/j.ijbiomac.2017.04.098. [Epub ahead of print] PMID: 28465178 </br>2:Corrigendum to /Therapeutic effect of ursolic acid in experimental visceral leishmaniasis/ [Int. J. Parasitol. Drugs Drug Resist. 7 (2017) 1-11]. Jesus JA, Fragoso TN, Yamamoto ES, Laurenti MD, Silva MS, Ferreira AF, Lago JHG, Santos-Gomes G, Passero LFD.Int J Parasitol Drugs Drug Resist. 2017 Apr 4. pii: S2211-3207(17)30038-6. doi: 10.1016/j.ijpddr.2017.04.001. [Epub ahead of print] No abstract available. PMID: 28433520 Free Article</br>3:New derivatives of ursolic acid through the biotransformation by Bacillus megaterium CGMCC 1.1741 as inhibitors on nitric oxide production. Zhang C, Xu SH, Ma BL, Wang WW, Yu BY, Zhang J.Bioorg Med Chem Lett. 2017 Jun 1;27(11):2575-2578. doi: 10.1016/j.bmcl.2017.03.076. Epub 2017 Mar 27. PMID: 28427811 </br>4:Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors. Wu PP, Zhang BJ, Cui XP, Yang Y, Jiang ZY, Zhou ZH, Zhong YY, Mai YY, Ouyang Z, Chen HS, Zheng J, Zhao SQ, Zhang K.Sci Rep. 2017 Mar 30;7:45578. doi: 10.1038/srep45578. PMID: 28358057 Free PMC Article</br>5:Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1α through reducing endogenous GSH and inhibiting HIF-1α. Song B, Zhang Q, Yu M, Qi X, Wang G, Xiao L, Yi Q, Jin W.Oncol Lett. 2017 Feb;13(2):754-762. doi: 10.3892/ol.2016.5468. Epub 2016 Dec 7. PMID: 28356955 Free PMC Article</br>6:Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways. Li L, Yin Y, Hou G, Han D, Kang J, Wang Q.Pulm Pharmacol Ther. 2017 Mar 24. pii: S1094-5539(16)30170-5. doi: 10.1016/j.pupt.2017.03.014. [Epub ahead of print] PMID: 28347799 </br>7:Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells. Cai Q, Lin J, Zhang L, Lin J, Wang L, Chen D, Peng J.Tumour Biol. 2017 Mar;39(3):1010428317695015. doi: 10.1177/1010428317695015. PMID: 28347227 </br>8:Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse. Tang FR, Loke WK, Wong P, Khoo BC.Physiol Behav. 2017 Jun 1;175:37-46. doi: 10.1016/j.physbeh.2017.03.027. Epub 2017 Mar 22. PMID: 28341234 </br>9:Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. Li W, Zhang H, Nie M, Tian Y, Chen X, Chen C, Chen H, Liu R.Acta Biochim Biophys Sin (Shanghai). 2017 Apr 1;49(4):367-373. doi: 10.1093/abbs/gmx012. PMID: 28338932 </br>10:Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review. Katashima CK, Silva VR, Gomes TL, Pichard C, Pimentel GD.Obes Rev. 2017 Jun;18(6):700-711. doi: 10.1111/obr.12523. Epub 2017 Mar 23. Review. PMID: 28335087 |
