USC-087

For research use only. Not for therapeutic Use.

  • CAT Number: I037892
  • Molecular Formula: C34H58N7O5P
  • Molecular Weight: 675.8558
  • Purity: 98%
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USC-087 is a N-alkyl tyrosinamide phosphonate ester prodrug of HPMPA, the adenine analog of cidofovir, and is highly effective against multiple AdV types in cell culture. USC-087 is a promising candidate for drug development against HAdV infections.


Catalog Number I037892
Synonyms

USC-087; USC087; USC 087

Molecular Formula C34H58N7O5P
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (4-((S)-1-amino-2-(hexadecylamino)-2-oxoethyl)benzyl)((((2S)-1-(6-amino-4,5-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphinic acid
InChI InChI=1S/C34H58N7O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-37-34(43)30(35)28-18-16-27(17-19-28)23-47(44,45)26-46-29(22-42)21-41-25-40-31-32(36)38-24-39-33(31)41/h16-19,24-25,29-31,33,42H,2-15,20-23,26,35H2,1H3,(H,37,43)(H,44,45)(H2,36,38,39)/t29-,30-,31?,33?/m0/s1
InChIKey HYGAPLJVCRVKAG-NOHNHAJDSA-N
SMILES NC1=NC=NC2C1N=CN2C[C@@H](CO)OCP(CC3=CC=C([C@H](N)C(NCCCCCCCCCCCCCCCC)=O)C=C3)(O)=O
Reference

1: Toth K, Spencer JF, Ying B, Tollefson AE, Hartline CB, Richard ET, Fan J, Lyu J, Kashemirov BA, Harteg C, Reyna D, Lipka E, Prichard MN, McKenna CE, Wold WSM. USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses. Antiviral Res. 2018 May;153:1-9. doi: 10.1016/j.antiviral.2018.03.001. Epub 2018 Mar 3. PubMed PMID: 29510156; PubMed Central PMCID: PMC5891362.

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