USL311

• CAT Number: I019332
• CAS Number: 1373268-67-7
• Molecular Formula: C₂₄H₃₄N₆O
• Molecular Weight: 422.57
• Purity: ≥95%
• Target: Immunology/Inflammation
• Storage: Store at -20°C
• IUPAC Name: 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-N-pyridin-4-ylpyridine-2-carboxamide
• InChI: InChI=1S/C24H34N6O/c1-19(2)28-15-9-21(10-16-28)29-13-4-14-30(18-17-29)23-6-3-5-22(27-23)24(31)26-20-7-11-25-12-8-20/h3,5-8,11-12,19,21H,4,9-10,13-18H2,1-2H3,(H,25,26,31)
• InChIKey: XNUNVQKARNSSEO-UHFFFAOYSA-N
• SMILES: CC(C)N1CCC(CC1)N2CCCN(CC2)C3=CC=CC(=N3)C(=O)NC4=CC=NC=C4

USL311（Cat No.:I019332） is a potent and selective CXCR4 antagonist that exhibits anti-tumor activity. It functions by blocking the interaction between stromal-cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4, a chemokine receptor involved in cell migration, proliferation, and survival. By inhibiting this interaction, USL311 hinders the signaling pathway mediated by CXCR4, which is critical for tumor progression and metastasis. Through its specific targeting of CXCR4, USL311 holds promise as a therapeutic agent in the treatment of various cancers and other diseases associated with CXCR4 signaling.

Reference

[1]. Peter Richardson. Usl-311 for use in the treatment of cancer. WO2018162924A1